Scientific paper on membranes

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Scientific paper on membranes

Discovery[ edit ] The word liposome derives from two Greek words: Liposomes were first described by British haematologist Alec D Bangham [6] [7] [8] in publishedat the Babraham Institute, in Cambridge.

They were discovered when Bangham and R.

Liposome - Wikipedia

Horne were testing the institute's new electron microscope by adding negative stain to dry phospholipids. The resemblance to the plasmalemma was obvious, and the microscope pictures served as the first evidence for the cell membrane being a bilayer lipid structure.

Their integrity as a closed, bilayer structure, that could release its contents after detergent treatment structure-linked latency was established by Bangham, Standish and Weissmann in the next year.


Around this time he was joined at Babraham by Gerald Weissmannan American physician with an interest in lysosomes.

Now an emeritus professor at New York University School of Medicine, Weissmann recalls the two of them sitting in a Cambridge pub and reflecting on the role of lipid sheets in separating the interior of the cell from the exterior milieu.

This insight, they felt, was to cell function what the discovery of the double helix had been to genetics.

Scientific paper on membranes

It was Weissmann who proposed the more user-friendly term liposome. Hydrophobic chemicals associate with the bilayer. To deliver the molecules to a site of action, the lipid bilayer can fuse with other bilayers such as the cell membranethus delivering the liposome contents; this is a complex and non-spontaneous event, however.

Liposome - Wikipedia

Liposomes can also be designed to deliver drugs in other ways. Liposomes that contain low or high pH can be constructed such that dissolved aqueous drugs will be charged in solution i. As the pH naturally neutralizes within the liposome protons can pass through some membranesthe drug will also be neutralized, allowing it to freely pass through a membrane.

These liposomes work to deliver drug by diffusion rather than by direct cell fusion.

ICIM – June 18–22, 2018

A similar approach can be exploited in the biodetoxification of drugs by injecting empty liposomes with a transmembrane pH gradient.

In this case the vesicles act as sinks to scavenge the drug in the blood circulation and prevent its toxic effect. Liposomes can be made in a particular size range that makes them viable targets for natural macrophage phagocytosis.

These liposomes may be digested while in the macrophage's phagosomethus releasing its drug. Liposomes can also be decorated with opsonins and ligands to activate endocytosis in other cell types.

The use of liposomes for transformation or transfection of DNA into a host cell is known as lipofection.

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In addition to gene and drug delivery applications, liposomes can be used as carriers for the delivery of dyes to textiles, [17] pesticides to plants, enzymes and nutritional supplements to foods, and cosmetics to the skin. Dietary and nutritional supplements[ edit ] Regarding the use of liposomes as a carrier of dietary and nutritional supplements; until very recently the use of liposomes were primarily directed at targeted drug delivery.

However, the versatile abilities of liposomes are now being discovered in other settings.RNAi, Oligos, Assays, Gene Editing & Gene Synthesis Tools Oligos Tools. Eurofins MWG Operon Oligos Tool. The International Conference on Inorganic Membranes (ICIM) is held every second year all over the world in rotation.

This series of conferences has been established as a global high-level event on inorganic membranes and innovations. Provides a complete portfolio of laboratory equipment, chemicals, supplies, and services used in scientific research, safety, healthcare, and education.

Reusing Cell Membranes: Diffusion and Osmosis kits Teachers will need to instruct students on how to handle clean-up and return of the re-usable kit materials.

Published: Mon, 5 Dec A cell is a dynamic and a complex structure surrounded by a membrane known as the plasma membrane. This acts like a barrier between the inside of the cell and the outside resulting in different chemical environments on the two sides.

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Journal of Membrane Science - Elsevier